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dc.contributor.author Schlader, Z. J.
dc.contributor.author Seifert, T.
dc.contributor.author Wilson, T. E.
dc.contributor.author Bundgaard-Nielsen, M.
dc.contributor.author Secher, N. H.
dc.contributor.author Crandall, C. G.
dc.date.accessioned 2019-12-05T21:03:28Z
dc.date.available 2019-12-05T21:03:28Z
dc.date.issued 2013-06-15
dc.identifier.citation Schlader ZJ, Seifert T, Wilson TE, Bundgaard-Nielsen M, Secher NH, Crandall CG. Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage. Journal of Applied Physiology 114: 1730-1735, 2013. en
dc.identifier.uri http://hdl.handle.net/2022/24859
dc.description Postprint, author's accepted manuscript en
dc.description.abstract Hyperthermia reduces the capacity to withstand a simulated hemorrhagic challenge, but volume loading preserves this capacity. This study tested the hypotheses that acute volume expansion during hyperthermia increases cerebral perfusion and attenuates reductions in cerebral perfusion during a simulated hemorrhagic challenge induced by lower-body negative pressure (LBNP). Eight healthy young male subjects underwent a supine baseline period (pre-LBNP), followed by 15- and 30-mmHg LBNP while normothermic, hyperthermic (increased pulmonary artery blood temperature ∼1.1°C), and following acute volume infusion while hyperthermic. Primary dependent variables were mean middle cerebral artery blood velocity (MCAvmean), serving as an index of cerebral perfusion; mean arterial pressure (MAP); and cardiac output (thermodilution). During baseline, hyperthermia reduced MCAvmean (P = 0.001) by 12 ± 9% relative to normothermia. Volume infusion while hyperthermic increased cardiac output by 2.8 ± 1.4 l/min (P < 0.001), but did not alter MCAvmean (P = 0.99) or MAP (P = 0.39) compared with hyperthermia alone. Relative to hyperthermia, at 30-mmHg LBNP acute volume infusion attenuated reductions (P < 0.001) in cardiac output (by 2.5 ± 0.9 l/min; P < 0.001), MAP (by 5 ± 6 mmHg; P = 0.004), and MCAvmean (by 12 ± 13%; P = 0.002). These data indicate that acute volume expansion does not reverse hyperthermia-induced reductions in cerebral perfusion pre-LBNP, but that it does attenuate reductions in cerebral perfusion during simulated hemorrhage in hyperthermic humans. en
dc.language.iso en en
dc.publisher Journal of Applied Physiology en
dc.relation.isversionof https://www.physiology.org/doi/full/10.1152/japplphysiol.00079.2013 en
dc.subject lower-body negative pressure en
dc.subject heat stress en
dc.subject brain blood flow en
dc.subject volume infusion en
dc.title Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage en
dc.type Article en
dc.identifier.doi 10.1152/japplphysiol.00079.2013


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