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dc.contributor.author Bouchard, C. en
dc.contributor.author Blair, S.N. en
dc.contributor.author Church, T.S. en
dc.contributor.author Earnest, C.P. en
dc.contributor.author Slentz, C.A. en
dc.contributor.author Rankinen, T. en
dc.date.accessioned 2014-07-08T18:53:48Z en
dc.date.available 2014-07-08T18:53:48Z en
dc.date.issued 2012 en
dc.identifier.citation Bouchard, C., Blair, S. N., Church, T. S., Earnest, C. P., Hagberg, J. M., Hakkinen, K., . . . Rankinen, T. (2012). Adverse metabolic response to regular exercise: Is it a rare or common occurrence? PLoS ONE, 7(5). http://dx.doi.org/10.1371/journal.pone.0037887 en
dc.identifier.uri http://hdl.handle.net/2022/18487
dc.description.abstract Background: Individuals differ in the response to regular exercise. Whether there are people who experience adverse changes in cardiovascular and diabetes risk factors has never been addressed. Methodology/Principal Findings: An adverse response is defined as an exercise-induced change that worsens a risk factor beyond measurement error and expected day-to-day variation. Sixty subjects were measured three times over a period of three weeks, and variation in resting systolic blood pressure (SBP) and in fasting plasma HDL-cholesterol (HDL-C), triglycerides (TG), and insulin (FI) was quantified. The technical error (TE) defined as the within-subject standard deviation derived from these measurements was computed. An adverse response for a given risk factor was defined as a change that was at least two TEs away from no change but in an adverse direction. Thus an adverse response was recorded if an increase reached 10 mm Hg or more for SBP, 0.42 mmol/L or more for TG, or 24 pmol/L or more for FI or if a decrease reached 0.12 mmol/L or more for HDL-C. Completers from six exercise studies were used in the present analysis: Whites (N = 473) and Blacks (N = 250) from the HERITAGE Family Study; Whites and Blacks from DREW (N = 326), from INFLAME (N = 70), and from STRRIDE (N = 303); and Whites from a University of Maryland cohort (N = 160) and from a University of Jyvaskyla study (N = 105), for a total of 1,687 men and women. Using the above definitions, 126 subjects (8.4%) had an adverse change in FI. Numbers of adverse responders reached 12.2% for SBP, 10.4% for TG, and 13.3% for HDL-C. About 7% of participants experienced adverse responses in two or more risk factors. Conclusions/Significance: Adverse responses to regular exercise in cardiovascular and diabetes risk factors occur. Identifying the predictors of such unwarranted responses and how to prevent them will provide the foundation for personalized exercise prescription. en
dc.language.iso en_US en
dc.publisher Public Library of Science en
dc.relation.isversionof https://doi.org/10.1371/journal.pone.0037887 en
dc.rights © 2012, Bouchard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by/3.0/ en
dc.subject high density lipoprotein cholesterol en
dc.subject insulin en
dc.subject triacylglycerol en
dc.subject high density lipoprotein cholesterol en
dc.subject insulin en
dc.subject triacylglycerol en
dc.subject African American en
dc.subject article en
dc.subject cardiovascular risk en
dc.subject Caucasian en
dc.subject cholesterol blood level en
dc.subject diabetes mellitus en
dc.subject exercise en
dc.subject human en
dc.subject insulin blood level en
dc.subject metabolism en
dc.subject risk factor en
dc.subject systolic blood pressure en
dc.subject triacylglycerol blood level en
dc.subject United States en
dc.subject adult en
dc.subject aged en
dc.subject basal metabolic rate en
dc.subject blood en
dc.subject blood pressure en
dc.subject cardiovascular disease en
dc.subject diet restriction en
dc.subject epidemiology en
dc.subject female en
dc.subject kinesiotherapy en
dc.subject male en
dc.subject middle aged en
dc.subject Aged en
dc.subject Basal Metabolism en
dc.subject Blood Pressure en
dc.subject Cardiovascular Diseases en
dc.subject Cholesterol, HDL en
dc.subject Diabetes Mellitus en
dc.subject Epidemiologic Studies en
dc.subject Exercise en
dc.subject Exercise Therapy en
dc.subject Fasting en
dc.subject Female en
dc.subject Humans en
dc.subject Insulin en
dc.subject Male en
dc.subject Metabolism en
dc.subject Middle Aged en
dc.subject Risk Factors en
dc.subject Triglycerides en
dc.title Adverse metabolic response to regular exercise: Is it a rare or common occurrence? en
dc.type Article en


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